Applications are now being received from prospective international PhD students for the 2014 University of Warwick PhD studentship in Mechanistic Modelling. The programme starts September 29 and will run for three years.
The scholarship is awarded by the School of Engineering and it is a Research based studentship. Students are awarded a PhD in Engineering (PhD)
The project is titled: Mechanistic modelling of in vitro transporter data to improve translational modelling of the transporter-mediated human pharmacokinetics and DDI predictions
Transporters have been shown to play critical role in drug pharmacokinetics, pharmacodynamics, targeted or site specific delivery, toxicological effects, therapeutic efficacy and drug-drug interactions. The use of in vitro systems models to predict in vivo responses provides the benefits of requiring fewer animals, reducing variability between samples, requiring less test material, and enabling higher throughput. This project will develop mathematical models of in vitro transporter data to compartmentalise systems into physiologically distinct regions whilst also accounting for various physicochemical and biological uptake/efflux processes to provide insight into these biological mechanisms. Such development will simultaneously yield models that can be used in a predictive capacity to optimise experimental conditions in order to robustly generate kinetic and inhibition parameters for in vitro/in vivo correlations and physiologically based pharmacokinetic modelling.
Worth of Award
- The award is worth £18,000 per annum
- This will provide doctoral training to develop expertise in cellular assays, analytical LC-MS methodologies and mathematical modelling tools.
- The skills developed will equip the student for a future career in a wide range of pharmaceutical and biotechnology sciences.
- The expected starting date is September 2014.
- The studentship covers the cost of tuition fees and provides an annual tax-free stipend of £18,000 for three years.
- Candidates must have a first or upper second class honours degree or significant research experience.
- Candidates for BBSRC training awards must normally hold a first or upper second class UK honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of science or technology.
- They will ask that you submit the online application and upload your CV and transcripts.
How to Apply
- To apply for this post you must complete the online application form and quote scholarship reference MJC14.
- As soon as you have a University ID number you will be invited to upload your degree certificate, transcripts, CV and a personal statement that explains your specific research interests and why you should be considered for this award.
- You can obtain application form from their website (see link below): .
- Interested candidates should in the first instance contact Dr Michael Chappell via: [email protected] or +44(0)24 765 24309.